1189-71-5Relevant articles and documents
Method for synthesizing chlorosulfonyl isocyanate by continuous method
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Paragraph 0049-0064, (2021/02/06)
The invention provides a method for synthesizing chlorosulfonyl isocyanate by a continuous method, wherein the method comprises the following steps: A) reacting cyanogen chloride with sulfur trioxidein a first-stage static mixer, feeding the reacted material into a continuous falling film separation device, and separating to obtain gas-phase chlorosulfonyl isocyanate and a liquid-phase six-membered ring by-product; and B) introducing the six-membered ring by-product into a continuous falling film decomposer, carrying out heating decomposition to obtain chlorosulfonyl isocyanate, cyanogen chloride and sulfur trioxide, and returning the cyanogen chloride and sulfur trioxide as raw materials to the first-stage static mixer for reuse. Through segmented reaction and separation, the effects ofreducing the generation of solid wastes and improving the utilization rate of the raw materials are achieved. Experimental results show that the purity of the chlorosulfonyl isocyanate directly obtained through the method is about 97.0%, the one-way yield of the chlorosulfonyl isocyanate is larger than 75.0%, the cyclic yield of the chlorosulfonyl isocyanate is larger than 95.0%, and almost no solid residues exist in a decomposition evaporator.
SULFONYLIMIDE SALT AND METHOD FOR PRODUCING THE SAME
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Page/Page column 10, (2011/02/26)
The present invention provides a method for producing fluorosulfonylimides more safely, rapidly and efficiently, which enables suppression of production of by-products, and fluorosulfonylimides. The method for producing a fluorosulfonylimide salt of the present invention includes a step of reacting a fluoride compound containing at least one element selected from the group consisting of elements of Group 11 to Group 15 and Period 4 to Period 6 (excluding arsenic and antimony) with a compound represented by the following general formula (I) to give a fluorosulfonylimide salt represented by the general formula (II): wherein R1 denotes at least one element selected from the group consisting of elements of Group 11 to Group 15 and Period 4 to Period 6 (excluding arsenic and antimony); R3 denotes fluorine, chlorine or a fluorinated alkyl group having 1 to 6 carbon atoms; R4 denotes fluorine or a fluorinated alkyl group having 1 to 6 carbon atoms; and m denotes an integer of 2 or 3.
5-Cyano-prostacyclin derivatives
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, (2008/06/13)
Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula STR1 wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is --CH2 --CH2 --, cis--CH=CH--, trans--CH=CH-- or --C C--, W is free or functionally modified hydroxymethylene or free or functionally modified STR2 wherein the OH-group can be in the α- or β-position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases.
